陈正平

个人简历

主要从事神经系统分子影像探针的研发，为神经系统疾病的诊断、治疗发及疗效监测提供合适的探针药物。主持完成了国家自然科学基金（4项）、江苏省科技支撑计划、江苏省自然科学基金、江苏省医学重点项目等基金国家级、省部级科研项目等多项。主持完成的科研成果包括：国家一类新药临床批件2件；国家发明专利30余项，发表SCI论文40余篇，获得华夏医学科技奖、中国商业科技奖、江苏省医学新技术奖、江苏医药科技奖等。

研究室现有工作人员3人，其中高级职称2人，中级职称1人。带教药物化学、核药学专业硕士研究生6人。研究室具有独立的药物合成实验室、药物分析实验室、分子生物学实验室等，同时共享国家卫健委核医学重点实验室、江苏省分子核医学重点实验室的科研平台，具有优良的科研条件。研究室长期招收博士、硕士研究生，培养药学、药物化学、放射性药物领域的专业人才，欢迎有志于相关领域的学生报考。

承担科研课题

1.    国家自然科学基金（82172054），氟[¹⁸F]标记的氘代tropane用于多巴胺转运体PET精准显像的实验研究，2022-2025，项目负责人

2.    江苏省自然科学基金（BK20201133），新型氟[¹⁸F]标记的中枢神经系统DAT显像药物的合成与实验研究，2022-2024，项目负责人

近五年代表性论文

[1] Liu C, Fang Y, Tang J, Chen Z. Derivatization of dihydrotetrabenazine for technetium-99m labelling towards a radiotracer targeting vesicular monoamine transporter 2. Arabian Journal of Chemistry, 2023, 16: 104572.   https://www.sciencedirect.com/science/article/pii/S1878535223000333

[2] Li Q, Hu Q, Tang J, Fang Y, Liu C, Liu J, Qi M, Chen Z, Zhang L. Deuterated [¹⁸F]fluoroethyl tropane analogs as dopamine transporter probes: Synthesis and biological evaluation. Nuclear Medicine and Biology, 2023, 118-119: 108334.   https://www.ncbi.nlm.nih.gov/pubmed/37028197

[3] Hu Q, Li Q, Tang J, Liu J, Fang Y, Liu C, Qi M, Chen Z. Synthesis and biological evaluation of ¹⁸F-labelled deuterated tropane derivatives as dopamine transporter probes. Arabian Journal of Chemistry, 2023, 16: 105278.   https://www.sciencedirect.com/science/article/pii/S1878535223007402

[4] Fang Y, Liu C, Tang J, Pei Z, Chen Z. Visible-Light Photocatalytic Synthesis of Difluoromethylated Selenides from Selenosulfonates through a Radical Process. The Journal of Organic Chemistry, 2023, 88: 12658-12667.   https://doi.org/10.1021/acs.joc.3c01352

[5] Ji L, Fang Y, Tang J, Liu C, Huang C, Hu Q, Li Q, Chen Z. Synthesis and biological evaluation of ¹⁸F-labelled dopamine D₃ receptor selective ligands. Bioorganic & Medicinal Chemistry Letters, 2022, 62: 128630.   https://doi.org/10.1016/j.bmcl.2022.128630

[6] Huang C, Liu C, Tang J, Fang Y, Ji L, Hu Q, Li Q, Xie M, Chen Z. Development and validation of high-performance liquid chromatography method for analysis of β-CCT and its related substances. Arabian Journal of Chemistry, 2022, 15: 103725.   https://doi.org/10.1016/j.arabjc.2022.103725

[7] Xu Y, Tang J, Liu C, Zhao C, Cao S, Yu H, Chen Z, Xie M. MicroPET imaging of vesicular monoamine transporter 2 revealed the potentiation of (+)-dihydrotetrabenazine on MPTP-induced degeneration of dopaminergic neurons. Nuclear Medicine and Biology, 2021, 96-97: 9-18.   https://www.ncbi.nlm.nih.gov/pubmed/33647803

[8] Liu C, Tang J, Xu Y, Cao S, Fang Y, Zhao C, Chen Z. Molar activity of [¹⁸F]FP-(+)-DTBZ radiopharmaceutical: Determination and its effect on quantitative analysis of VMAT2 autoradiography. Journal of Pharmaceutical and Biomedical Analysis, 2021, 203: 114212.   https://www.ncbi.nlm.nih.gov/pubmed/34153939

[9] Fang Y, Li X, Liu C, Tang J, Chen Z. Nucleophilic Substitution of Selenosulfonates with Me₃SiCF₂Br: Facile and Efficient Access to Bromodifluoromethylated Selenides under Metal-Free Conditions. Journal of Organic Chemistry, 2021, 86: 18081-18093.   https://www.ncbi.nlm.nih.gov/pubmed/34823360

[10] Cao S, Tang J, Liu C, Fang Y, Ji L, Xu Y, Chen Z. Synthesis and Biological Evaluation of [¹⁸F]FECNT-d₄ as a Novel PET Agent for Dopamine Transporter Imaging. Molecular Imaging and Biology, 2021, 23: 733-744.   https://www.ncbi.nlm.nih.gov/pubmed/33851345