于妍妍

个人简历

江苏省“六大人才高峰”和“333工程”高层次人才培养对象，江苏省“青蓝工程”优秀青年骨干教师，校青年特聘教授，研究生教育优秀导师。2012年毕业于华东师范大学，同年进入徐州医科大学药物分析教研室工作。博士期间，荣获教育部“博士研究生学术新人奖”。博士毕业论文被评为上海市优秀学术论文。以第一和通讯作者在Angew. Chem. Int. Edit、Anal. Chem、Chem. Commun等高水平杂志发表SCI论文35篇，包括一区论文19篇。申请发明专利3项，其中1项已授权。主持国家自然科学基金面上和青年基金各1项，江苏省自然科学基金1项，江苏省高校自然科学基金重大项目1项，中国博士后科研基金多项等10余项课题。指导多名研究生获得国家奖学金。承担药学、药物制剂、临床药学专业《分析化学》的理论及实验教学。主持hg8868官网国家一流专业建设课题重点项目1项，《分析化学》获得江苏省高效在线开放课程（排名第2）。获得2022年度校“课程思政”示范课。指导本科生获得大学生创新创业计划3项，“药苑论坛”创新成果一、二等奖及优秀论文奖。发表教学论文3篇，参编科学出版社《分析化学》教材1部。

承担科研课题

1.      国家自然科学基金面上项目，21675137，基于多孔聚离子液体生物载体的AD大鼠脑中复合标志物的同步在体分析，2017/01-2020/12，65万元，主持；

2.      国家自然科学基金青年基金，基于系列性功能化离子液体的微渗析在体电化学分析方法的研究与应用，21205102，2013/01-2015/12，23万元，主持；

3.      江苏省自然科学基金，BK20161170，纳米级超微修饰电极对AD中多种复合标志物的同步在体分析，2016/07-2019/06，10万元，主持；

4.      江苏省自然科学基金，BK20201457，多功能MOFs复合材料对AD小鼠神经元细胞内ATP 和Aβ寡聚体的荧光传感和成像分析，2020/09-2023/06，10万元，主持；

5.      江苏省高等学校自然科学研究重大项目，17KJA350004，活体电化学技术对β-淀粉蛋白聚集化程度的定量评估，2017/07-2020/06，30万元，主持；

6.      中国博士后科研基金特别资助，2016T90504，纳米级超微修饰电极对AD中多种标志物的同步在体分析，2016/04-2018/04，15万元，主持；

7.      中国博士后科研基金面上项目，2015M580471，双通道纳米碳纤维电极对Aβ单体及寡聚体的在体分析，2015/01-2016/12，8万元，主持；

8.      江苏省第五期“333工程”科研资助项目，纳米级超微修饰电极对AD中多种复合标志物的同步在体分析，2016/12-2018/12，4万元，主持；

9.      徐州医科大学青年科技创新团队，重大疾病标志物的检测、探寻及应用，2019/01-2022/12，20万元，主持；

10.  徐州医科大学优博人才项目，D2012010，微渗析在体电化学分析方法的建立及在脑神经科学中的应用，2013/06-2016/06，30万元，主持。

近五年代表性论文、专著

1.      Yifan Zuo, Wenwen Lu, Yi Xia, Jiali Meng, Yi Zhou, Yang Xiao, Liang Zhu, Duanjiao Liu, Shenhao Yang, Yuqing Sun, Chenglin Li,* Yanyan Yu*, Glucometer Readout for Portable Detection of Heterogeneous Circulating Tumor Cells in Lung Cancer Captured on a Dual Aptamer Functionalized Wrinkled Cellulose Hydrogel Interface, ACS Sens., 2023, 8, 187-196. (IF: 9.618，一区)

2.      Yuanyuan Hu, Xinguang Zhou, Liming Wang, Jinyu Gu, Yingchun Zuo, Li Zhao, Wenwen Lu, Yanyan Yu*, A liposome-based aptasensor integrated with competitive reaction enabling portable and electrochemical detection of Aβ oligomer, Biosens. Bioelectron., 2023, 225, 115108. (IF: 12.545，一区)

3.      Yifan Zuo, Yi Xia, Wenwen Lu, Yue Li, Yang Xiao, Shuai Gao, Zhiyi Zhou, Hao Xu, Xingqing Feng, Chenglin Li*, Yanyan Yu*, A multifunctional black phosphorus nanosheets based immunomagnetic bio-interface for heterogenous circulating tumor cell capture and simultaneous self-identification in gastric cancer patients, Nanoscale., 2023, 15, 3872-3883. (IF: 8.307，二区)

4.      Liang Ji, Xinguang Zhou, Runduo Liu, Liming Wang, Yuanyuan Hu, Jinyu Gu, Zhe Li, Chenglin Li, Tonghui Huang* , Yanyan Yu*, Design of a selective and water-soluble fluorescent probe targeting Tau fibrils for intracellular and in vivo imaging, Sensor Actuat B-Chem., 2023, 380, 133415. (IF: 9.221，一区)

5.      Chenglin Li, Rui Li, Xueyuan Wu, Yifan Zuo, Guixiang Xiong, Meng Huang, Yuqing Sun, Rong Liao, Yang Xiao, Lili Hu, Chao Gao, Yanyan Yu*, Capture of Heterogeneous Circulating Tumor Cells in Colorectal Cancer Patients on an Immunomagnetic and Anti-Nonspecific Adsorption Platform, Anal. Chem., 2022, 94, 15240-15249. (IF: 8.008，一区)

6.      Chenglin Li, Shenhao Yang, Rui Li, Shuyuan Gong, Meng Huang, Yuqing Sun, Guixiang Xiong, Dengpan Wu, Miaojin Ji, Yan Chen, Chao Gao, Yanyan Yu*, Dual aptamer targeted immunomagnetic nanoparticles to accurately explore the correlations between circulating tumor cells and gastric cancer, ACS Appl. Mater. Interfaces., 2022, 14, 7646-7658. (IF: 10.383，二区)

7.      Xinran Shi, Liang Ji, Yuanyuan Hu, Jinyu Gu, Liming Wang, Wenwen Lu, Jiali Meng, Yan Du, Lingzhong Huang, Dongxia Nie*, Yanyan Yu*, Dual-responsive zeolitic imidazolate framework-90 for the combined detection and intracellular imaging of ATP and ROS, Sensor Actuat B-Chem., 2022, 363, 131848. (IF: 9.221，一区)

8.      Liang Zhu, Xingqing Feng, Shenhao Yang, Jianyun Wang, Yixin Pan, Jinhua Ding, Chenglin Li, Xiaoxing Yin*, Yanyan Yu*, Colorimetric detection of immunomagnetically captured rare number CTCs using mDNA-wrapped single-walled carbon nanotubes, Biosens. Bioelectron. 2021, 172, 112780. (IF:10.618，一区)

9.      Chenglin Li, Xingqing Feng, Shenhao Yang, Hao Xu, Xiaoxing Yin,* Yanyan Yu*, Capture, Detection, and Simultaneous Identification of Rare Circulating Tumor Cells Based on a Rhodamine 6G-Loaded MetalOrganic Framework, ACS Appl. Mater. Interfaces., 2021, 13, 52406-52416. (IF:10.383，二区)

10.  Xueyan Yan, Yixin Pan, Liang Ji, Jinyu Gu, Yuanyuan Hu, Yi Xia, Chenglin Li, Xinguang Zhou, Dongzhi Yang, Yanyan Yu*, Multifunctional metal-organic framework as a versatile nanoplatform for Aβ oligomer imaging and chemo-photothermal treatment in living cells, Anal. Chem., 2021, 93, 13823-13834. (IF: 8.008，一区)

11.  Qiwen Peng, Xinran Shi, Xueyan Yan, Liang Ji, Yuanyuan Hu, Guoyue Shi, Yanyan Yu*, Electrochemical Strategy for Analyzing the Co-evolution of Cu 2+ and • OH Levels at the Early Stages of Transgenic AD Mice, ACS Appl. Mater. Interfaces., 2020, 12, 42595-42603. (IF:9.229，二区)

12.  Qiwen Peng, Xueyan Yan, Xinran Shi, Shanshan Ou, Hui Gu, Xiaoxing Yin*, Guoyue Shi, Yanyan Yu*, In vivo monitoring of superoxide anion from Alzheimer's rat brains with functionalized ionic liquid polymer decorated microsensor, Biosens. Bioelectron. 2019, 144, 111665-111672. (IF: 10.257，一区)

13.  Yanyan Yu, Tianxiao Yin, Qiwen Peng, Lingna Kong, Chenglin Li, Daoquan Tang*, Xiaoxing Yin*, Simultaneous Monitoring of Amyloid-β (Aβ) Oligomers and Fibrils for Effectively Evaluating the Dynamic Process of Aβ Aggregation, ACS Sens. 2019, 4 (2), 471-478. (IF: 6.94，一区)

14.  Yanyan Yu, Yuan Yang, Jinhua Ding, Si Meng, Chenglin Li*, Xiaoxing Yin*, Design of A Biocompatible and Ratiometric Fluorescent probe for the Capture, Detection, Release and Reculture of rare number CTCs, Anal. Chem. 2018, 90, 13290-13298. (IF: 6.35，一区)