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招生就业
微生物与生化药学

齐素华

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发布时间:2020年05月26日
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齐素华,教授,博士,博士生导师

科学研究方向

心脑血管疾病药物筛选与诊断标志物、脑病分子机制和脑病细胞信号转导

联系方式

电 话:0516-83262502

Emailsuhuaqi@xzhmu.edu.cn

通 讯:江苏省徐州市云龙区铜山路209号,221004

个人简历

江苏省“333高层次人才培养工程”第三层次培养对象,江苏省高校“青蓝工程”普通高校优秀青年骨干教师,徐州市第三届优秀科技工作者。现任徐州医科大学学术委员会委员、江苏省神经学会委员、江苏省脑病学会委员、淮海科技奖专家库成员。主持国家自然科学基金面上项目2项,部省级重大项目10余项。以第一作者或通讯作者发表SCI论文30余篇,参编本科教材2部。

承担科研课题

1.    国家自然科学基金,81671164SIRT1通过介导β-catenin核转位靶向引导神经干细胞(NSCs)促进中风神经再生的研究,2017.01-2020.1260万元,主持。

2.    国家自然科学基金,81171075PAR1对脑出血Src介导的NMDA受体酪氨酸磷酸化调控机制的研究,2011.01-2014.1260万元,主持。

3.    国家自然科学基金,81271344Wnt5a通过β-arrestin2组装的信号模块介导脑出血JNK3激活的信号通路的研究,2013.01-2016.1275万元,参与。

4.    江苏省自然科学基金,13KJA310005Cav-1通过eNOS-Cav-1-β-Catenin信号模块介导脑缺血再灌注后Wnt通路激活的研究,2013.01-2017.1215万元,主持。

5.    江苏省自然科学基金(江苏省六大人才高峰资助),苦瓜多糖通过eNOS-Cav-1-β-Catenin信号模块介导脑缺血再灌注后Wnt通路激活作用的研究,2013.01-2016.123万元,主持。

6.    江苏省自然科学基金,11KJB310012PAR1对脑出血Src介导的NMDA受体酪氨酸磷酸化调控机制的研究,2012.01-2013.123万元,主持。

7.    江苏省自然科学基金,08KJB180010,酒精通过KA受体负性调控脑缺血再灌注后JNK3激活的研究,2008.01-2011.123万元,主持。

8.    江苏省自然科学基金,04KJD310207,脑缺血再灌注后大鼠海马区ERK5/MEF2信号通路及作用的研究,2005.01-2007.121万元,主持。

9.    徐州医学院人才基金,2010KJZ13,苦瓜活性成分对出血性脑损伤保护作用机制的研究,2010.01-2012.123万元,主持。

10.国家自然科学基金,30870543KA受体亚基GluR6巯基亚硝酸化在缺血性脑中风中的作用,2009.01-2011.1230万元,参与。

11.国家自然科学基金,30330190GluR6•PSD-95•MLKs信号模块介导脑中风JNK通路的激活和调控及作用的研究,2006.01-2009.1250万元,参与。

12.大学生创新计划,2015103130Z,苦瓜多糖的提取与纯化及其对神经再生作用机制的研究,2015.01-2017.121万元。

近五年代表性论文、专著

1.    Hansen Chen, Binghe Guan, Xiaoyu Bai, Xi Chen, Dan Yang, Kejian Liu, Qi Wang, Suhua Qi*, Jiangang Shen*. Glycyrrhizin inhibits peroxynitrite-mediated HMGB1/TLR2/MMP-9 signaling cascades prevents hemorrhagic transformation and promotes outcome in ischemic stroke with delayed thrombolysis. Translational Stroke Research. 2020.

2.    Hansen Chen, Binghe Guan, Xi Chen, Xingmiao Chen, Caiming Li, Jinhua Qiu, Dan Yang, Ke Jian Liu, Suhua Qi*, Jiangang Shen*. Baicalin Attenuates Blood-Brain Barrier Disruption and Hemorrhagic Transformation and Improves Neurological Outcome in Ischemic Stroke Rats with Delayed t-PA Treatment: Involvement of ONOO-MMP-9 Pathway. Translational Stroke Research. 2018, 9(5):515-529.

3.    Xue Wen Wei, JuanJuan Gong, Juyun Ma, Taiyu Zhang, Yihang Li, Ting Lan, Peng Guo, Su Hua Qi*. Targeting the Dvl-1/β-arrestin2/JNK3 Interaction Disrupts Wnt5a-JNK3 Signaling and Protects Hippocampal CA1 Neurons During Cerebral Ischemia Reperfusion. Neuropharmacology, 2018, 135, 11-21.

4.    Qiaoli Li, Nan Chen, Heng Cai,Yu Tang,Xiaoyan Zhou,Yue Huang,Muxin Gong, Cunyu Qin, XuewenWei, Suhua Q. Analysis of Momordica Charantia Polysaccharide Components and Their Effects on KA-Induced Oxidative Stress and Neuronal Loss in the Hippocampus of Epileptic Rats. World Journal of Neuroscience, 2018, 8, 113-123.

5.    Xu N, Fan W, Zhou X, Liu Y, Ma P, Qi S, et al. Probiotics decrease depressive behaviors induced by constipation via activating the AKT signaling pathway. Metab Brain Dis. 2018, 33:1625-1633.

6.    Chen HS, Qi SH, Shen JG*. One-Compound-Multi-Target: Combination Prospect of Natural Compounds with Thrombolytic Therapy in Acute Ischemic Stroke. Curr Neuropharmacol. 2017, 15(1):134-156. 

7.    Zhen-Zhen Duan, Feng Zhang, Feng-Ying Li, Yi-Fei Luan, Peng Guo, Yi-Hang Li, Yong Liu, Su-Hua Qi*. Protease activated receptor 1 (PAR1) enhances Src-mediated tyrosine phosphorylation of NMDA receptor in intracerebral hemorrhage (ICH). Sci Rep. 2016, 6:29246.

8.    Lingyun Hao, Xuewen Wei, Peng Guo, Guangyi Zhang‡ and Suhua Qi*. Neuroprotective Effects of Inhibiting Fyn S-Nitrosylation on Cerebral Ischemia/Reperfusion-Induced Damage to CA1 Hippocampal Neurons. Int J Mol Sci. 2016,17(7) 1100-1113.

9.    Wei XW, Hao LY, Qi SH*. Inhibition on the S-nitrosylation of MKK4 can protect hippocampal CA1 neurons in rat cerebral ischemia/reperfusion. Brain Res Bull. 2016, 124:123-128.

10.Juan-Juan Gong, Fu-Mou Sun, Zhen-Zhen Duan, Su-Hua Qi*, Jian-Gang Shen*. Momordica charantia polysaccharides could protect against cerebral ischemia/reperfusion injury through inhibiting oxidative stress mediated c-Jun N-terminal kinase 3 signaling pathway. Neuropharmacology, 2015, 91(1): 123-134.

11.Han Sen Chen, Xing Miao Chen, Jing Han Feng, Ke Jian Liu, Su-Hua Qi*, Jian Gang Shen*.  Peroxynitrite Decomposition Catalyst Reduces Delayed Thrombolysis-induced Hemorrhagic Transformation in Ischemia-reperfused Rat Brains. CNS Neuroscience & Therapeutics, 2015, 1-6.

12.Chen HS, Qi SH, Shen JG*. One-Compound-Multi-Target: Combination Prospect of Natural Compounds with Thrombolytic Therapy in Acute Ischemic Stroke. Curr Neuropharmacol. 2015 Dec 7. Epub ahead of print

13.SH Qi, LY Hao, YY Zong, J Yue, GY Zhang*. Activation of p38 Mitogen-activated Protein Kinase via S-nitrosylation and Phosphorylation by Nitric Oxide. Neuropathology & Applied Neurobiology, 2015, 39, 284–297.

 

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